Doctors have long known that womb tumor is caused by obesity, however, as yet, the result of losing weight on precancerous changes in the womb have been badly studied. The research led by University of Manchester and Salford Royal researchers is published today in International Journal of Cancer and funded by the NIHR Manchester Biomedical Research Center. Around 9, a year are identified as having womb cancer 000 women, of which 2,300 women perish. Pre-menopausal women treated for womb tumor by surgery lose the ability to have children. The 72 women with the average BMI of over 50-considered to be very obese-had biopsies extracted from their wombs during gastric sleeve or bypass surgery.
Of the 72, four were found to have womb cancers, that was treated by hysterectomy. A further six patients acquired atypical endometrial hyperplasia, a precancerous condition that triggers the overgrowth of cells in the womb. Of the six women with endometrial hyperplasia, three got no indications of the condition when re-tested at eight weeks, after losing around three stones in weight. The rest of the three were treated by a Mirena coil, which releases the hormone progesterone into the womb and reverses precancerous changes.
Two were been shown to be free of the problem after six months. Six monthly investigations over four years revealed the precancerous cells did not return for these five women; the last acquired a hysterectomy. The remaining 62 women acquired normal womb cells at the right time of weight loss surgery, but it …Continue reading